MITOCHONDRIAL TARGETED RNA EXPRESSION SYSTEM AND USE THEREOF
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United States of America Patent
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Issued Date -
Feb 5, 2015
app pub date -
Oct 10, 2014
filing date -
Apr 11, 2012
priority date (Note) -
Abandoned
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Abstract
Described herein is a mitochondrial-targeted RNA expression system (mtTRES) for delivery of RNA molecules to mitochondria. mtTRES vectors generate RNAs in vivo that are un-capped, non-polyadenylated, and actively directed to mitochondria. The disclosed vectors are capable of delivering either non-coding RNA molecules or RNA molecules encoding a protein of interest to the mitochondria. In particular, the disclosed vectors include (1) an RNAPIII initiation (promoter) sequence, (2) a non-coding leader sequence (NCL), (3) a mitochondrial translation initiation sequence and an ORF encoding a protein of interest, or a sequence encoding a non-coding RNA, and (4) an RNAPIII termination sequence.
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