Materials and methods for treatment of cystic fibrosis and for induction of ion secretion
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United States of America Patent
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Oct 2, 2018
Grant Date -
Feb 12, 2015
app pub date -
Mar 15, 2013
filing date -
Apr 5, 2012
priority date (Note) -
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Abstract
The present invention provides materials and methods for inducing ion secretion and/or for treating cystic fibrosis. In one embodiment, the composition comprises glucose and/or a non-metabolizable glucose analog and/or non-structural protein (NSP4), a NSP4 peptide, or a NSP4 toxoid as the active ingredient, formulated with pharmaceutically-acceptable carriers. In a preferred embodiment, the composition is in a form of an aerosol preparation for intranasal and/or pulmonary administration, and is used to stimulate chloride and fluid secretion in nasal, tracheal and/or bronchial epithelium.
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