FVIIa-sTF complexes exhibiting exosite-mediated super activity
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United States of America Patent
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Issued Date -
Feb 12, 2015
app pub date -
Mar 15, 2013
filing date -
Mar 30, 2012
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Abandoned
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Abstract
Disclosed are disulphide-linked complexes of a soluble Tissue Factor (sTF) variant of SEQ ID NO:3 comprising the mutation G109C and a Factor VIIa variant of SEQ ID NO. 1, comprising the mutation Q64C and a mutation at position M306 that gives rise to a zymogen-like conformation in the Factor VIIa polypeptide. Said complexes may be used for the treatment of a coagulopathy.
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