Methods and compositions for treatment of a genetic condition

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United States of America Patent

PATENT NO 9873894
SERIAL NO

14278903

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Methods and compositions comprising single guide RNAs targeted to an endogenous mammalian β globin gene (HBB), gamma globin gene (HBG1), B-cell lymphoma/leukemia 11A (BCL11A) gene, Kruppel-like factor 1 (KLF1) gene, CCR5 gene, CXCR4 gene, PPP1R12C (AAVS1) gene, hypoxanthine phosphoribosyltransferase (HPRT) gene, albumin gene, Factor VIII gene, Factor IX gene, Leucine-rich repeat kinase 2 (LRRK2) gene, Hungtingin (Htt) gene, rhodopsin (RHO) gene, Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene, surfactant protein B gene (SFTPB), T-cell receptor alpha (TRAC) gene, T-cell receptor beta (TRBC) gene, programmed cell death 1 (PD1) gene, Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) gene, human leukocyte antigen (HLA) A gene, a LMP7 gene, a Transporter associated with Antigen Processing (TAP) gene, tapasin gene (TAPBP), a class II major histocompatibility complex transactivator (CIITA) gene, a dystrophin gene (DMD), a glucocorticoid receptor gene (GR), IL2RG gene or RFX5 for genetic alteration of cells are provided.

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Patent Owner(s)

  • SANGAMO THERAPEUTICS, INC.

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Conway, Anthony Richmond, US 31 480
Cost, Gregory J Richmond, US 27 1556
Dekelver, Russell Richmond, US 20 650
Rebar, Edward J Richmond, US 90 3886
Reik, Andreas Richmond, US 30 787
Urnov, Fyodor Richmond, US 106 4605
Wang, Jianbin Richmond, US 53 1130
Zhang, H Steve Richmond, US 34 961

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