USE OF ENGINEERED VIRUSES TO SPECIFICALLY KILL SENESCENT CELLS
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United States of America Patent
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Mar 5, 2015
app pub date -
Apr 16, 2013
filing date -
Apr 17, 2012
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Abstract
Polypeptides, viruses, methods and compositions provided herein are useful for the selective elimination of senescent cells. Method aspects include methods for inducing apoptosis in a senescent cell comprising administering to the cell a polynucleotide, virus, host cell, or pharmaceutical composition described herein. Other methods include expressing a pro-apoptotic gene in a senescent cell comprising administering to the cell the polynucleotide, virus, or pharmaceutical composition as described herein.
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