Engineered primate L-methioninase for therapeutic purposes

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United States of America Patent

PATENT NO 9481877
SERIAL NO

14472750

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Abstract

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Methods and compositions relating to the engineering of an improved protein with methionine-γ-lyase enzyme activity are described. For example, in certain aspects there may be disclosed a modified cystathionine-γ-lyase (CGL) comprising one or more amino acid substitutions and capable of degrading methionine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with methionine depletion using the disclosed proteins or nucleic acids.

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Patent Owner(s)

  • BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Georgiou, George Austin, US 111 1782
Lu, Wei-Cheng Austin, US 16 69
Stone, Everett Austin, US 45 226

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