METHODS AND COMPOSITIONS FOR 6-PHOSPHOGLUCONATE DEHYDROGENASE (6-PGD) AS A TARGET FOR LUNG CANCER THERAPY
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United States of America Patent
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Mar 5, 2015
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Apr 4, 2013
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Apr 4, 2012
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Abstract
The present invention relates to methods, compositions, and diagnostic tests for treating and diagnosing a proliferative disease that result in dysregulation of 6-phosphogluconate dehydrogenase. In particular, the methods and compositions include treatment of gefitinib/erlotinib resistant proliferative diseases such as lung cancer using a 6-phosphogluconate dehydrogenase antagonist.
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