PHARMACEUTICAL COMPOSITIONS AND DOSAGE FORMS FOR ADMININISTRATION OF HYDROPHOBIC DRUGS
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United States of America Patent
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app pub date -
Nov 7, 2014
filing date -
Jun 30, 1999
priority date (Note) -
Abandoned
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Abstract
Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs are provided. The pharmaceutical compositions include a therapeutically effective amount of a hydrophobic drug, preferably a steroid; a solubilizer, and a surfactant. The synergistic effect between the hydrophobic drug and the solubilizer results in a pharmaceutical formulation with improved dispersion of both the active agent and the solubilizer. As a result of the improved dispersion, the pharmaceutical composition has improved bioavailability upon administration. Methods of improving the bioavailability of hydrophobic drugs administered to a patient are also provided.
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