High affinity Sirp-alpha reagents and methods of using

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United States of America Patent

PATENT NO 9944911
SERIAL NO

14371370

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Abstract

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High affinity SIRP-α reagent are provided, which (i) comprise at least one amino acid change relative to the wild-type protein; and (ii) have an increased affinity for CD47 relative to the wild-type protein. Compositions and methods are provided for modulating phagocytosis in a mammal by administering a therapeutic dose of a pharmaceutical composition comprising a high affinity SIRPα reagent, which blocks the physiological binding interaction between SIRPα and its ligand CD47.

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Patent Owner(s)

  • THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Garcia, Kenan Christopher Menlo Park, US 65 188
Levin, Aron M Basking Ridge, US 7 72
Ring, Aaron Michael Palo Alto, US 28 253
Weiskopf, Kipp Andrew Menlo Park, US 27 155
Weissman, Irving L Stanford, US 179 1889

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