DIFFERENTIATED HUMAN LIVER CELL CULTURES AND THEIR USE IN BIOARTIFICIAL LIVER SYSTEMS

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United States of America Patent

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14541164

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Abstract

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Human hepatocyte cell cultures and their use in bioreactors and bioartificial liver (BAL) systems are provided. The cells have constitutive liver-specific metabolic activity resembling that of freshly isolated human hepatocytes. The hepatocyte cells and BAL systems can be used to treat patients suffering from acute liver failure, end-stage liver disease, or acute-on-chronic liver disease.

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Patent Owner(s)

Patent OwnerAddress
ACADEMISCH ZIEKENHUIS BIJ DE UNIVERSITEIT VAN AMSTERDAMAMSTERDAM AMSTERDAM NORTH HOLLAND

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
CHAMULEAU, Robert Antoine Francois Marie BUSSUM, NL 1 0
HOEKSTRA, Ruurdtje WEESP, NL 3 8
NIBOURG, Gerardus Adrianus Antonius AMSTERDAM, NL 2 8

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