HEPATOCYTES IN CO-CULTURE AND USES THEREOF
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United States of America Patent
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Mar 19, 2015
app pub date -
Jul 3, 2014
filing date -
Jul 3, 2013
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Abstract
The present disclosure provides a human hepatocyte co-culture which maintains the phenotype of cells from human donors with diabetes, and methods of using same. The hepatocyte co-culture system provides an in vitro model in which both cell viability and phenotype are maintained for extended periods relative to primary human hepatocyte monocultures, and is used in methods for high throughput screening and evaluation of drug candidates, and kits for performing such testing.
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