Importance

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Abstract

A compound of the general formula (III): wherein X is O, S, NH or CH₂; Y is O, S or NH; Z is O, S or CH₂; R₁ is C_1-8 alkyl, especially C_1-6 alkyl, preferably n-alkyl, e.g., n-pentyl or n-hexyl; at least one of R₂ and R₃ is H—[R₄-R₅]_n—R₆—, in which: H—[R₄-R₅]_n— comprises an oligopeptide, R₄ being an amino acid and R₅ being an amino acid selected from proline, alanine, hydroxyproline, dihydroxyproline, thiazolidinecarboxylic acid (thioproline), dehydroproline, pipecolic acid (L-homoproline), azetidinecarboxylic acid, aziridinecarboxylic acid, glycine, serine, valine, leucine, isoleucine and threonine, R₆ is a neutral, non-polar amino acid moiety that is bonded to R₅ by a peptide bond, and n is 1, 2, 3, 4 or 5; and the other of R₃ and R₂ is H—[R₄-R₅]_n—R₆— or H; or a pharmaceutically acceptable salt thereof.

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First Claim