BIOMARKERS FOR MONITORING INTERVENTION THERAPIES FOR DIABETES
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United States of America Patent
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Issued Date -
Mar 26, 2015
app pub date -
Apr 16, 2013
filing date -
Apr 20, 2012
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Abstract
The use of N-linked glycosylation pattern of serum proteins as a biomarker for evaluating the efficacy of intervention therapies for diabetes is disclosed. As disclosed herein, changes in the N-linked glycosylation of total plasma proteins precedes and predicts the decrease in glycated hemoglobin (HbA1c) associated with successful treatment of diabetes. Therefore, measuring changes in N-linked glycosylation of total serum plasma proteins over time may be used as a biomarker to evaluate or access the efficacy of an intervention therapy for diabetes.
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