CRYSTAL STRUCTURE OF HCV POLYMERASE COMPLEXES AND METHODS OF USE
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United States of America Patent
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Issued Date -
Mar 26, 2015
app pub date -
Jan 11, 2013
filing date -
Jan 13, 2012
priority date (Note) -
Abandoned
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Abstract
The present disclosure includes a crystalline form and a crystal structure of HCV RNA polymerase and HCV RNA polymerase in a complex with an RNA template primer molecule. In other aspects, the disclosure provides methods of using the crystal structures and structural coordinates to identify homologous proteins and to design or identify agents that can modulate the function of the HCV RNA polymerase and HCV RNA polymerase in a complex with an RNA template primer molecule.
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