BIODEGRADABLE POLYURETHANES AND USE THEREOF

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United States of America Patent

APP PUB NO 20150093821A1
SERIAL NO

14511370

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Abstract

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A biodegradable and biocompatible polyurethane composition synthesized by reacting isocyanate groups of at least one multifunctional isocyanate compound with at least one bioactive agent having at least one reactive group —X which is a hydroxyl group (—OH) or an amine group (—NH2). The polyurethane composition is biodegradable within a living organism to biocompatible degradation products including the bioactive agent. Preferably, the released bioactive agent affects at least one of biological activity or chemical activity in the host organism. A biodegradable polyurethane composition includes hard segments and soft segments. Each of the hard segments is preferably derived from a diurea diol or a diester diol and is preferably biodegradable into biomolecule degradation products or into biomolecule degradation products and a biocompatible diol. Another biodegradable polyurethane composition includes hard segments and soft segments. Each of the hard segments is derived from a diurethane diol and is biodegradable into biomolecule degradation products.

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Patent Owner(s)

Patent OwnerAddress
PITTSBURGH UNIVERSITY OF200 GARDNER STEEL CONFERENCE CENTER THCKERAY & O'HARA STREETS PITTSBURGH PA 15260

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Beckman, Eric J Aspinwall, US 47 711
Doll, Bruce A Wexford, US 2 98
Guelcher, Scott A Thompson Station, US 28 386
Hollinger, Jeffrey O Gibsonia, US 17 497
Zhang, Jianying Pittsburgh, US 31 183

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