Iron Chelators as HIV-1 Inhibitors
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United States of America Patent
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Apr 30, 2015
app pub date -
Mar 14, 2013
filing date -
May 9, 2012
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Abstract
The present invention relates to chelator compounds for chelating metal ions. In particular, the present invention relates to (thio)semicarbazone compounds and (thio)hydrazone compounds, such as PpYeT and PpYaT, which are chelators for metal ions, including iron ions. Therapeutic use of such compounds and/or their metal ion complexes, includes methods for treating and inhibiting HIV-1 replication, particularly in HIV-1 infected cells.
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