MULTIMODAL IMAGING METHODS USING MESOPOROUS SILICA NANOPARTICLES
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United States of America Patent
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May 7, 2015
app pub date -
Mar 13, 2013
filing date -
May 11, 2012
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Abstract
The invention provides particles useful for sequential imaging or for diagnostics or therapeutics. Disclosed is a method to image diagnostic or therapeutic cells in a mammal, comprising: introducing to a mammal a composition comprising mammalian cells comprising mesoporous silica nanoparticles (MSNs) comprising a lanthanide, a fluorophore and an agent detectable by ultrasound; applying ultrasound and/or a magnetic field to the mammal and recording ultrasound and/or magnetic resonance images that include the MSNs; and detecting the presence, location or amount of the MSNs in the mammal.
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