Active protease-resistant antibody FC mutants

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United States of America Patent

PATENT NO 9611328
APP PUB NO 20150139984A1
SERIAL NO

14492250

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Abstract

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The present invention relates to modified Fc-containing molecules including modified antibodies characterized by increased resistance to host and pathogen-derived proteases, ability to interact with FcγR receptors except with FcγRI, and lack of induction of IL-10 secretion by macrophages, and methods of using and making them.

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Patent Owner(s)

  • JANSSEN BIOTECH, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Brezski, Randall Spring House, US 11 86
Jordan, Robert Thorton, US 63 1109
Strohl, William Spring House, US 17 160

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