CARRIER FOR INTRACELLULAR DELIVERY OF FUNCTIONAL PROTEIN
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United States of America Patent
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Issued Date -
May 21, 2015
app pub date -
Sep 19, 2012
filing date -
Mar 21, 2012
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Abandoned
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Abstract
A liposome comprising a lipid covalently bonded with a polyarginine peptide consisting of 4 to 20 continuous arginine residues and a lipid covalently bonded with a GALA peptide consisting of the amino acid sequence of SEQ ID NO: 1 and/or an R-GALA peptide consisting of the amino acid sequence of SEQ ID NO: 2 as component lipids of lipid membrane, and having a lipid membrane in which a protein to be intracellularly delivered is non-covalently bound to outer surface of the membrane, which is for quickly and conveniently deriver a functional protein, especially such a protein having a high molecular weight, into a cell.
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