Pharmaceutical Compositions Of Metabotropic Glutamate 5 Receptor (MGLU5) Antagonists

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United States of America Patent

SERIAL NO

14538434

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Abstract

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Pharmaceutical compositions of metabotropic glutamate 5 receptor (mGlu5) antagonists or a pharmacologically acceptable salt thereof are disclosed. The compositions contain the therapeutic active compound with non-ionic polymer and ionic polymer, binder and fillers in either matrix pellet, matrix tablet or coated pellets. The compositions provide a pH-independent in vitro release profile with NMT 70% in one hour, NMT 85% in 4 hour, and NLT 80% in 8 hours. The compositions are useful for the treatment of CNS disorders, such as Treatment-Resistant Depression (TRD) and Fragile X Syndrome.

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Patent Owner(s)

Patent OwnerAddress
F HOFFMANN-LA ROCHE AGSWITZERLAND ZUG ZUG

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chatterji, Ashish East Brunswick, US 27 42
Huang, Jingjun Monmouth Junction, US 17 23
Koennings, Stephanie Bottmingen, CH 8 4
Lindenstruth, Kai Loerrach, DE 11 6
Sandhu, Harpreet West Orange, US 11 6
Shah, Navnit Clifton, US 12 129

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