Fixing tissue samples using nitrogen-containing compounds that release aldehydes

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United States of America Patent

PATENT NO 10345202
APP PUB NO 20150140601A1
SERIAL NO

14532252

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Abstract

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A method (100) for fixing at least one tissue sample (1) is carried out using a tissue processor (10). The tissue sample (1) is introduced at a first temperature level and a first pressure level into a fixing reagent (2) containing at least one nitrogen-containing compound capable of pressure- and/or temperature-dependent release of at least one aldehyde. The tissue sample (1) is left in the fixing reagent (2) for a fixing time period during which the fixing reagent (2) is brought to a second temperature level above the first temperature level and/or to a second pressure level above the first pressure level. A concentration in the fixing reagent (2) of the nitrogen-containing compound is ascertained using at least one concentration measuring device (14) of the tissue processor (10), and a signal is outputted on the basis of a measured value of the at least one concentration measuring device (14).

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Patent Owner(s)

  • LEICA BIOSYSTEMS NUSSLOCH GMBH

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Berberich, Markus Heidelberg, DE 22 50
Ulbrich, Hermann Bad Schönborn, DE 29 92

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