Prostate-specific membrane antigen antibody drug conjugates

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United States of America Patent

PATENT NO 10800856
APP PUB NO 20150152190A1
SERIAL NO

14406190

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Abstract

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This invention relates to prostate-specific membrane antigen (PSMA) antibodies and antibody drug conjugates comprising at least one non-naturally-encoded amino acid. Disclosed herein are αPSMA antibodies with one or more non-naturally encoded amino acids and further disclosed are antibody drug conjugates wherein the αPSMA antibodies of the invention are conjugated to one or more toxins. Also disclosed herein are non-natural amino acid dolastatin analogs that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such dolastatin analogs. Typically, the modified dolastatin analogs include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid antibody drug conjugates, dolastatin analogs, and modified non-natural amino acid dolastatin analogs, including therapeutic, diagnostic, and other biotechnology uses.

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Patent Owner(s)

Patent OwnerAddress
AMBRX INC10975 NORTH TORREY PINES ROAD LA JOLLA CA 92037

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Barnett, Richard S San Marcos, US 10 129
Beck, Andrew San Diego, US 45 1819
Gymnopoulos, Marco San Diego, US 10 25
Knudsen, Nick Escondido, US 47 1108
Putnam, Anna-Maria A Hays San Diego, US 2 18
Sun, Ying San Diego, US 390 7529
Tian, Feng San Diego, US 160 3003

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