Polycarbonates bearing aromatic N-heterocycles for drug delivery

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United States of America Patent

PATENT NO 9717797
SERIAL NO

14097488

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Abstract

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Nanoparticles comprise a drug, a first block polymer and a second block polymer. The first block polymer has a poly(ethylene oxide) (PEO) block and a polycarbonate block bearing a side chain aromatic nitrogen-containing heterocycle (N-heterocycle). The N-heterocycle can be in the form of a base, a hydrosalt of the base, a sulfobetaine adduct of the base, or a combination thereof. The second block polymer has a PEO block and a polycarbonate block bearing a side chain catechol group, which can be present as a catechol, oxidized form of a catechol, and/or a polymerized form of a catechol. The nanoparticles can be dispersed in water and are capable of controlled release of the drug.

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Patent Owner(s)

  • AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH;INTERNATIONAL BUSINESS MACHINES CORPORATION;UNIVERSIDAD DEL PAIS VASCO/EUSKAL HERRIKO UNIBERTSITATEA;UNIVERSIDAD DEL PARÍS VASCO/EUSKAL HERRIKO UNIBERTSITATEA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chan, Julian M W Fremont, US 11 26
Engler, Amanda C San Jose, US 40 73
Hedrick, James L Pleasanton, US 294 1235
Ke, Xiyu Singapore, SG 6 14
Ng, Victor W L Singapore, SG 11 18
Sardon, Haritz San Jose, US 4 4
Tan, Jeremy P K Singapore, SG 6 9
Yang, Yi Yan Singapore, SG 115 481

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