ASTAXANTHIN PRODUCTION USING A RECOMBINANT MICROBIAL HOST CELL

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United States of America Patent

APP PUB NO 20150167041A1
SERIAL NO

14521625

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Abstract

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A recombinant microbial host cell is provided capable of producing astaxanthin from β-carotene without a measurable concomitant accumulation of ketolated or hydroxylated intermediates such as adonixanthin, zeaxanthin, adonirubin, echinenone, 3-hydroxyechinenone, 3′-hydroxyechinenone, canthaxanthin, and β-cryptoxanthin. Specifically, a β-carotene producing microbial host cell was engineered to express two heterologous genes, a β-carotene ketolase from Chlamydomonas reinhardtii in combination with a carotenoid hydroxylase from Brevundimonas vesicularis or Arabidopsis thaliana.

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Patent Owner(s)

Patent OwnerAddress
E I DU PONT DE NEMOURS AND COMPANYCHESTNUT RUN PLAZA 974 CENTRE ROAD PO BOX 2915 WILMINGTON DE 19805

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Banerjee, Anirban West Bengal, IN 46 845
Cheng, Qiong Wilmington, US 83 583
Paradkar, Ashish Hyderabad, IN 3 2
SAMANTA, SUDIP KUMAR Hyderabad, IN 1 0
Sharpe, Pamela L Wilmington, US 22 92
Zhu, Quinn Qun West Chester, US 133 1511

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