Methods and Compositions for Modulating Beta Cell Proliferation
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United States of America Patent
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Issued Date -
Jun 25, 2015
app pub date -
Sep 27, 2012
filing date -
Sep 28, 2011
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Abandoned
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Abstract
Methods and compositions are provided for modulating pancreatic islet β cell proliferation. Aspects of the methods include promoting β cell proliferation by providing agents that promote PDGFR signaling, or inhibiting β cell proliferation by providing agents that inhibit PDGFR signaling. These methods find a number of uses, including, for example, in the treatment of diabetes and human islet diseases. Also provided are reagents and kits thereof that find use in practicing the subject methods.
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