Poxviral vectors for low antibody response after a first priming immunization

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United States of America Patent

PATENT NO 10111946
APP PUB NO 20150174238A1
SERIAL NO

14409309

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Abstract

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The invention is drawn to compositions and methods for the induction of an immune response, in particular a strong CD8 T cell response, to a specific antigenic determinant without raising a significant antibody response to the antigenic determinant after a first, priming immunization. The method comprises administering to the host a recombinant poxviral vector comprising a transcriptional control element comprising an early and/or late element linked to a nucleotide sequence encoding the antigenic determinant. The recombinant poxviral vector comprises a transcriptional control element comprising an early and/or late element linked to a nucleotide sequence encoding the antigenic determinant. The late element may be stronger than the cowpox ATI promoter in HeLa cells.

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Patent Owner(s)

  • BAVARIAN NORDIC A/S

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Brinkmann, Kay Munich, DE 7 39
Chaplin, Paul Grafelfing, DE 49 764
Dirmeier, Ulrike Starnberg, DE 10 10
Steigerwald, Robin Munich, DE 32 37

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