IgA CD4i ANTIBODIES AND METHODS OF TREATMENT USING SAME
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United States of America Patent
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Issued Date -
Jun 25, 2015
app pub date -
Jun 17, 2013
filing date -
Jun 15, 2012
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Abstract
The present invention relates to isolated IgA antibodies, or fragments thereof, which have variable domains derived from an antibody that specifically binds to a CD4-induced (CD4i) epitope. In particular, the isolated IgA antibodies display enhanced neutralization activity relative to their IgG, non-chimeric counterparts. The invention also provides methods for therapy with the isolated IgA antibodies for the treatment of a subject having a viral infection or having an increased risk of a viral infection.
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