FILAGGRIN PRODUCTION PROMOTER, THERAPEUTIC AGENT FOR DISEASES ASSOCIATED WITH REDUCTION IN PRODUCTION OF FILAGGRIN, AND METHOD FOR SCREENING FOR SAID THERAPEUTIC AGENT
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United States of America Patent
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Jul 9, 2015
app pub date -
Jul 12, 2013
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Jul 26, 2012
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Abstract
The present invention provides a highly effective substance having a filaggrin production-promoting action. The present invention also provides a therapeutic agent useful for treating a skin disease, in particular, atopic dermatitis associated with reduced filaggrin production. As a result of intensive studies on a filaggrin production promoter, it has been found that A) an N-quinolylbenzamide derivative (Compound 1), B) ivermectin (Compound 2), or C) a phenylalaninamide derivative (Compound 3) promotes production of filaggrin in skin and satisfactorily improves a water retention ability and barrier function of the stratum corneum. The present invention relates to a filaggrin production promoter containing a certain N-quinolylbenzamide derivative or a pharmaceutically acceptable salt thereof as an active ingredient.
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