METHODS OF USING CEO2 AND TIO2 NANOPARTICLES IN MODULATION OF THE IMMUNE SYSTEM
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United States of America Patent
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Jul 9, 2015
app pub date -
Jul 8, 2013
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Jul 6, 2012
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Abstract
Redox-active NPs are disclosed that can potentiate innate immunity and stimulate distinct adaptive responses, producing distinct T cell subset polarization outcomes. Nanomaterials that can alter the cellular redox environment through ROS modulation can impact human immunology. TiO2 nanoparticles potentiate DC maturation, inducing the secretion of IL-12, p70, and IL-1B, while treatment with CeO2 nanoparticles induces IL-10, a hallmark of suppression. When delivered to T cells, the materials direct distinct TH polarization, where TiO2 stimulates largely a TH1 dominated response, whereas CeO2 stimulates a TH2 bias and TReg differentiation.
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