Method and system for quantifying sequence alignment
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United States of America Patent
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Nov 10, 2020
Grant Date -
Jul 16, 2015
app pub date -
Oct 17, 2014
filing date -
Oct 18, 2013
priority date (Note) -
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status (Latency Note)
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Abstract
The invention includes methods for aligning reads (e.g., nucleic acid reads, amino acid reads) to a reference sequence construct, methods for building the reference sequence construct, and systems that use the alignment methods and constructs to produce sequences. The invention also includes methods and systems for evaluating the quality of the alignment between the reads and the reference sequence construct. The method is scalable, and can be used to align millions of reads to a construct thousands of bases or amino acids long. The invention additionally includes methods for identifying a disease or a genotype based upon alignment of nucleic acid reads to a location in the construct.
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