COMPOSITIONS AND METHODS FOR ENHANCING NEURONAL PHOSPHORYLATION HOMEOSTASIS, AND MODULATING DYSFUNCTIONAL EXOCYTOSIS AND NEUROTRANSMITTER RELEASE
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United States of America Patent
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Jul 23, 2015
app pub date -
Jan 22, 2015
filing date -
Jan 22, 2014
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Abstract
Provided are methods for treating pre-neuronal loss abnormalities in synaptic function, comprising administrating to a subject having neurons, an ionic aqueous solution comprising charge-stabilized oxygen-containing nanostructures having an average diameter of less than 100 nm in an amount and for a time period sufficient for preventing or reducing abnormalities in synaptic function that precede neuronal loss and/or NFTs formation in taupathies. Also provided are methods for treating pre-neuronal loss abnormalities in synaptic function, comprising contacting neurons in vitro or ex vivo with an ionic aqueous solution comprising charge-stabilized oxygen-containing nanostructures having an average diameter of less than 100 nm in an amount and for a time period sufficient for preventing or reducing abnormalities in synaptic function that precede neuronal loss and/or NFTs formation.
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