Cholate and deoxycholate-based amphiphiles for membrane protein manipulation
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United States of America Patent
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Feb 9, 2016
Grant Date -
Jul 23, 2015
app pub date -
Dec 1, 2014
filing date -
Dec 2, 2013
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Abstract
Disclosed are compounds and methods for manipulating proteins in general and membrane proteins in particular. The compounds can be prepared from cholic acid, deoxycholic acid, lithocholic acid, or derivatives thereof. The compounds typically possess critical micelle concentrations lower than those of known detergents such as CHAPS and CHAPSO. Accordingly, lower amounts of the compounds are required for effective solubilization of membrane proteins. The compounds can be used aid the solubilization, isolation, purification, stabilization, crystallization, and/or structural determination of membrane proteins.
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