TRANSGENIC NON-HUMAN ANIMAL AND USES THEREOF
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United States of America Patent
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Jul 30, 2015
app pub date -
Feb 4, 2015
filing date -
Dec 21, 2009
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Abstract
The present invention relates generally to transgene constructs, transgenic non-human animals comprising transgene constructs, methods of making and methods of using the transgenic non-human animals comprising transgene constructs. An embodiment of the invention relates to methods of assaying the activation of GPCR ligands non-invasively in whole animals, tissue slices, or in native cells using a transgenic model containing a bioluminescent transgene reporter system that is responsive to pathway following ligand binding of GPCR receptors.
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