TUMOR SELECTIVE ANTIBODIES SPECIFIC TO ONCOFETAL ANTIGEN/IMMATURE LAMININ RECEPTOR PROTEIN

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United States of America Patent

APP PUB NO 20150218287A1
SERIAL NO

14614331

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Abstract

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Disclosed are high affinity antibodies or antigen-binding fragments thereof, which bind an epitope that lies within the C-terminal region of oncofetal antigen (OFA)/immature laminin receptor protein (iLRP), and which do not substantially cross-react with mature OFA/LRP. The antibodies may be conjugated to cytotoxic moieties to enhance their therapeutic efficacy. Methods of making the antibodies and therapeutic and diagnostic uses thereof are also disclosed.

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Patent Owner(s)

Patent OwnerAddress
BENOVUS BIO INCATLANTA GA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Barsoum, Adel L Mobile, US 9 9
Coggin,, JR Joseph H Mobile, US 4 3
Johnson, Kent J Ann Arbor, US 5 2
Morgan, Alton C Savannah, US 5 2
Rohrer, James W Mobile, US 8 9
Sinkule, Joseph A Paradise Valley, US 2 0
Varani, James Ann Arbor, US 14 105

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