ANTI-COMPLEMENT THERAPY COMPOSITIONS AND METHODS FOR PRESERVING STORED BLOOD
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United States of America Patent
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app pub date -
Aug 30, 2013
filing date -
Aug 31, 2012
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Abstract
Provided herein is a composition comprising transfusable red blood cells having improved storage capability, wherein a C9 inhibitor has been administered to the composition and thereby the composition has a reduced amount of red blood cell lysis as compared to a control. It is a surprising finding of the present invention that addition of a C9 inhibitor to a blood sample decreases the amount of red cell lysis in the sample over time. Accordingly, the present invention provides red blood cell compositions that can be stored for greater lengths of time before use, i.e., transfusion, and/or that have a reduced amount of storage lesion.
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