Activation of innate immunity for enhanced nuclear reprogramming of somatic cells with mRNA

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United States of America Patent

PATENT NO 9738873
APP PUB NO 20150225699A1
SERIAL NO

14615955

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Abstract

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The nuclear reprogramming of somatic cells with mRNA encoding reprogramming factors is shown to be greatly accelerated by activation of innate immune responses in the somatic cell. Methods of activating innate immunity include activation of PKR, of toll-like receptors, e.g. TLR3, etc. In some embodiments the mRNA provides the activator of innate immunity.

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Patent Owner(s)

  • THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cooke, John P Houston, US 43 911
Yakubov, Eduard Houston, US 11 98

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