Importance

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Abstract

This disclosure generally relates to genetically engineered cells and methods of making and using such genetically engineered cells. Generally, the genetically engineered cells exhibit an increase in synthesis of an activated sugar-nucleotide compared to a wild type control. In some embodiments, the activated sugar-nucleotide produced by the genetically engineered cell is an activated sugar-nucleotide that is not natively synthesized by wild type, un-engineered cell. In some embodiments, the activated sugar-nucleotide is an activated uridine diphosphate sugar nucleotide. In other embodiments, the activated sugar-nucleotide is an activated cysteine monophosphate sugar nucleotide. In still other embodiments, the activated sugar-nucleotide is an activated guanosine diphosphate sugar nucleotide. In some embodiments, the activated sugar-nucleotide includes an isotopic label.

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First Claim