NOVEL ATTENUATED DENGUE VIRUS STRAINS FOR VACCINE APPLICATION

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United States of America Patent

SERIAL NO

14430099

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Abstract

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The present invention discloses a method of eliciting an immune response and a method of vaccination comprising administration of a mutated flavivirus. The mutated flavivirus comprises at least one mutation in a nucleic acid sequence encoding for the non-structural protein 5 of the flavivirus sequence resulting in inactivation of the 2′O-methyltransferase.

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Patent Owner(s)

Patent OwnerAddress
NOVARTIS AGBASEL SUI BASEL BASEL-STADT

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fink, Katja Singapore, SG 15 48
Qin, Cheng Feng Singapore, SG 1 0
Shi, Pei-Yong Singapore, SG 23 34

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