METHODS AND PRODUCTS FOR TREATING PROLIFERATIVE DISEASES
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United States of America Patent
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Issued Date -
Aug 20, 2015
app pub date -
May 5, 2015
filing date -
Jul 14, 2008
priority date (Note) -
Abandoned
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Abstract
Methods and products for treating proliferative diseases, and wounds, using as a pharmacon an autophagy inhibitor, a glycolytic inhibitor, and/or an agent able to alter cellular production of reactive oxygen, or combination thereof, optionally in combination with one or more chemotherapeutic agents. In some embodiments, the invention combines a 4-aminoquinoline, exemplified by chloroquine, with a glycolytic inhibitor, exemplified by 2-deoxy-D-glucose and anti-VEGF antibodies. The systems and methods of the invention may be used to treat drug-resistant or multi-drug resistant cancers
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