HYPERPOLARIZED 2-OXOGLUTARATE AS METABOLIC AGENT IN MR
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Oct 1, 2015
app pub date -
Oct 24, 2013
filing date -
Oct 25, 2012
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Abstract
Hyperpolarized 1-13C-2-oxoglutarate as contrast agent in 13C Magnetic Resonance diagnostic technique (13C-MRI) for use in the diagnosis of cancer. In particular, upon administration of said 1-13C-2-oxoglutarate, signals of 1-13C-glutamate are detected. More in particular, different MR signals from 13C nuclei are detected and compared, said comparison being useful to determine a difference between tumor and non-tumor tissues, to determine the aggressiveness of a tumor or the efficacy of an anti-tumor therapy.
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