Multi-day patch for the transdermal administration of rotigotine

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United States of America Patent

PATENT NO 11389410
APP PUB NO 20150290142A1
SERIAL NO

14443210

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Abstract

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The present invention relates to a transdermal therapeutic system, comprising (a) a backing layer, (b) a solvent-based self-adhesive matrix layer containing rotigotine as active ingredient, and (c) a release liner, wherein the self-adhesive matrix layer has a coating weight of about 75-400 g/m2 and comprises a reservoir layer containing about 9-25 wt.-% rotigotine based on the weight of the reservoir layer, a kit comprising two transdermal therapeutic systems of the present invention as well as a method for the preparation of the transdermal therapeutic system of the present invention. In addition, the present invention relates to a transdermal therapeutic system comprising rotigotine as active ingredient for use in the treatment of patients suffering from Parkinson's disease, Parkinson's plus syndrome, depression, fibromyalgia and the restless-legs syndrome and for use in the treatment or prevention of dopaminergic neuron loss or cognitive disorders by transdermal administration of rotigotine once or twice weekly, wherein the transdermal therapeutic system comprises a backing layer, a solvent-based rotigotine containing self-adhesive matrix layer as well as a release liner and is adapted to allow for the transdermal administration of therapeutically effective amounts of rotigotine for at least 3 days.

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Patent Owner(s)

Patent OwnerAddress
LTS LOHMANN THERAPIE-SYSTEME AGLOHMANNSTRASSE 2 ANDERNACH 56626

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cawello, Willi Monheim, DE 7 51
Emgenbroich, Marco Rheinbach, DE 30 42
Kassner, Kristina Bergisch Gladbach, DE 4 8
Lappert, Aurelia Woluwe Saint Pierre, BE 2 6
Leonhard, Johannes Josef Bendorf, DE 8 27
Müller, Walter Andernach, DE 187 3128
Wolff, Hans-Michael Monheim, DE 36 617

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