Papanicolaou test for ovarian and endometrial cancers

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United States of America Patent

PATENT NO 11525163
APP PUB NO 20150292027A1
SERIAL NO

14439041

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The recently developed liquid-based Papanicolaou (Pap) smear allows not only cytologic evaluation but also collection of DNA for detection of HPV, the causative agent of cervical cancer. We tested these samples to detect somatic mutations present in rare tumor cells that might accumulate in the cervix once shed from endometrial and ovarian cancers. A panel of commonly mutated genes in endometrial and ovarian cancers was assembled and used to identify mutations in all 46 endometrial or cervical cancer tissue samples. We were able also able to identify the same mutations in the DNA from liquid Pap smears in 100% of endometrial cancers (24 of 24) and in 41% of ovarian cancers (9 of 22). We developed a sequence-based method to query mutations in 12 genes in a single liquid Pap smear without prior knowledge of the tumor's genotype.

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Patent Owner(s)

  • THE JOHNS HOPKINS UNIVERSITY

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bettegowda, Chetan Perry Hall, US 14 34
Diaz, Luis Ellicott City, US 69 462
Kinde, Isaac Beaumont, US 6 640
Kinzler, Kenneth W Baltimore, US 282 4776
Papadopoulos, Nickolas Towson, US 90 1073
Vogelstein, Bert Baltimore, US 324 6303
Wang, Yuxuan Baltimore, US 25 306

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