Pharmaceutical core-shell composite powder and processes for making the same

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United States of America Patent

PATENT NO 9801820
APP PUB NO 20150297521A1
SERIAL NO

14441970

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Abstract

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A composite particle including a core with at least one carrier material; a fluidizing material layer on the surface of the core; and an outer layer comprising nanoparticles of an ingestible material distributed in at least one matrix-forming material. A process of making the composite particles includes the steps of dry coating carrier particles with a fluidizing material; preparing a suspension of nanoparticles of an ingestible material distributed in a matrix-forming material; and fluid bed coating the carrier particles with the suspension. The process and products provide quick dissolving composite particles which can be used for delivery of poorly water soluble ingestible materials in suitable dosage forms. The process of the invention reduces or prevents particle agglomeration during fabrication of the composite particles to enable delivery and quick redispersion of nanoparticles of the ingestible material from a dosage form.

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Patent Owner(s)

Patent OwnerAddress
NEW JERSEY INSTITUTE OF TECHNOLOGY323 DR MARTIN LUTHER KING JR BLVD UNIVERSITY HEIGHTS NEWARK NJ 07102

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Azad, Mohammed A Harrison, US 1 5
Bilgili, Ecevit A Woodbridge, US 2 9
Dave, Rajesh Princeton, US 13 276
Knieke, Catharina Ludwigshafen, DE 2 26
To, Daniel North Wales, US 9 39

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