Controlling the activity of growth factors, particularly TGF-β, in vivo

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United States of America Patent

PATENT NO 10092891
APP PUB NO 20150306220A1
SERIAL NO

14261586

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Abstract

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TGF-β growth factor and its latent complex are conjugated to magnetic micro- or nanoparticles and to magnetic micro- or nanodiscs. By exposing the resulting conjugates to magnetic fields, the TGF-β growth factor can be released from its latent complex in vivo, potentially making it useful in tissue engineering and regenerative medicine. And by exposing a conjugate of TGF-β growth factor and a magnetic particle to a sufficiently strong, radiofrequency magnetic field, the TGF-β growth factor can be denatured and thereby deactivated, potentially making it possible to avoid triggering tumorigenesis, atherosclerosis, fibrotic disease, and cancer.

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Patent Owner(s)

  • UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dobson, Jon P Gainesville, US 9 3
Monsalve, Adam Gainesville, US 1 0

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