PROCESS FOR PREPARING STABLE ANTIBODY MAYTANSINOID CONJUGATES
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United States of America Patent
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Issued Date -
Oct 29, 2015
app pub date -
Oct 4, 2013
filing date -
Oct 4, 2012
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Abandoned
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Abstract
The invention provides processes for manufacturing cell-binding agent-cytotoxic agent conjugates of improved stability comprising performing the modification reaction at a high pH. The inventive processes comprise contacting a cell-binding agent with a bifunctional crosslinking reagent in a solution having a pH of 7.1 to 9 to covalently attach a linker to the cell-binding agent and thereby prepare a mixture comprising cell-binding agents having linkers bound thereto.
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