MONOCLONAL ANTIBODIES AGAINST ACTIVATED PROTEIN C (aPC)
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United States of America Patent
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Issued Date -
Oct 29, 2015
app pub date -
Nov 27, 2013
filing date -
Nov 29, 2012
priority date (Note) -
Abandoned
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Abstract
Provided herein are antibodies, antigen-binding antibody fragments (Fabs), and other protein scaffolds, directed against human activated Protein C (aPC) with minimal binding to its zymogen Protein C (PC). Moreover, these aPC binding proteins could potentially block the anti-coagulant activity of aPC to induce coagulation. Therapeutic uses of these binders are described herein as are methods of panning and screening specific antibodies.
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