COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCERS ASSOCIATED WITH A DEFICIENCY IN THE MRE11/RAD50/NBS1 DNA DAMAGE REPAIR COMPLEX
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United States of America Patent
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Issued Date -
Nov 5, 2015
app pub date -
Nov 27, 2013
filing date -
Nov 28, 2012
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Abandoned
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Abstract
Provided are compositions and methods for the identification and treatment of cancers exhibiting reduced MRE11/RAD50/NBS1 (MRN) complex formation and/or functionality as well as methods for the identification and use of cytotoxic agents, including clastogenic agents, for the treatment of cancers exhibiting reduced MRN complex formation and/or functionality. Also provided are methods for detecting and treating cancers, in particular breast cancers, such as hormone-negative breast cancers (HNBCs) and triple-negative breast cancers (TNBCs), colorectal cancers, urothelial cancers, and other cancers that exhibit reduced MRN complex formation and/or functionality and are correspondingly sensitive to growth and/or survival inhibition by one or more cytotoxic agents.
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