Identification of an inhibitor of iRhom1 or an inhibitor of iRhom2

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United States of America Patent

PATENT NO 10024844
APP PUB NO 20150316538A1
SERIAL NO

14654139

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Abstract

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Disclosed are methods for treating a subject with an EGFR dependent pathology. The method comprises the step of administering to the subject an effective amount of an agent (“First Agent”) that decreases the biological activity of iRhom1 and an effective amount of an agent (“Second Agent”) that decreases the biological activity of iRhom2. Alternatively, the method comprises the step of administering to the subject an effective amount of an agent (“First Agent”) that modulates formation of a complex between iRhom 1 and TACE and an effective amount of an agent (“Second Agent”) that modulates formation of a complex between TACE and iRhom2. Also disclosed are assays for identifying such agents.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITY HEALTH NETWORK190 ELIZABETH STREET R FRASER ELLIOTT BUILDING ROOM 1S-417 TORONTO M5G 2C4

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Blobel, Carl New York, US 7 0
Mak, Tak Wah Toronto, CA 11 45
Maretzky, Thorsten New York, US 2 0
McIlwain, David Toronto, CA 2 0

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