CANCER PROGNOSIS AND THERAPY BASED ON SYNTHEIC LETHALITY
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May 14, 2015
filing date -
May 15, 2014
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Abstract
Systems and methods for identifying synthetic lethal (SL) and synthetic dosage lethal (SDL) interactions and networks are provided. Further provided are methods for predicting cancer gene essentiality, drug efficacy and survival of cancer patients using data-driven identification of synthetic lethality in cancer are provided. Novel drug candidates and drug combinations for use in cancer therapy and method for prioritizing existing cancer therapies are also provided.
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