GENETICALLY MODIFIED MAJOR HISTOCOMPATIBILITY COMPLEX MICE
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United States of America Patent
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app pub date -
Aug 19, 2015
filing date -
Feb 22, 2013
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Abandoned
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Abstract
The invention provides genetically modified non-human animals that express chimeric human/non-human MHC I and MHC II polypeptides and/or human or humanized β2 microglobulin polypeptide, as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified animals and methods of making the same. Methods of using the genetically modified animals to study various aspects of human immune system are provided.
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